A Short Review on Cardiotonic Steroids and Their Aminoguanidine Analogues
نویسندگان
چکیده
A short review on cardiotonic steroids and their analogues is presented. The natural, semisynthetic and synthetic derivatives, as well as their mechanism of action and structure-activity relationships are shown, with a special reference to aminoguanidine derivatives.
منابع مشابه
Advances in understanding the role of cardiac glycosides in control of sodium transport in renal tubules.
Cardiotonic steroids have been used for the past 200 years in the treatment of congestive heart failure. As specific inhibitors of membrane-bound Na(+)/K(+) ATPase, they enhance cardiac contractility through increasing myocardial cell calcium concentration in response to the resulting increase in intracellular Na concentration. The half-minimal concentrations of cardiotonic steroids required to...
متن کاملIntroducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review
Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for many years. The importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. In recent years, with the spread of parasite resistance to CQ and cross-resist...
متن کاملA Structural View on the Functional Importance of the Sugar Moiety and Steroid Hydroxyls of Cardiotonic Steroids in Binding
CAPSULE Background: Cardiotonic steroids are specific inhibitors of Na,K-ATPase important for treatment of congestive heart failure. Results: The sugar moiety and the steroid hydroxyls are pivotal for inhibition and pH-dependence. Conclusion: The sugar moiety is necessary for closing the access pathway for cardiotonic steroids. Significance: Knowledge of structural and functional features of ca...
متن کاملCardiotonic steroids on the road to anti-cancer therapy.
The sodium pump, Na(+)/K(+)-ATPase, could be an important target for the development of anti-cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion and its aberrant expression and activity are implicated in the development and progression of different cancers. Cardiotonic steroids, known ligands of the sodium pump have been widely used for the treatment ...
متن کاملThe role of cardiotonic steroids in the pathogenesis of cardiomyopathy in chronic kidney disease.
Cardiotonic steroids (CTS) are a new class of hormones that circulate in the blood and are divided into two distinct groups, cardenolides, such as ouabain and digoxin, and bufadienolides, such as marinobufagenin, telocinobufagin and bufalin. They have the ability to bind and inhibit the ubiquitous transport enzyme sodium potassium pump, thus regulating intracellular Na(+) concentration in every...
متن کامل